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Article

Basolateral chloride transporters in autosomal dominant polycystic kidney disease.

Pflugers Archiv : European journal of physiology - 1 Sept 2002

Lebeau Catherine, Hanaoka Kazushige, Moore-Hoon Marilyn L, Guggino William B, Beauwens Renaud, Devuyst Olivier

Abstract excerpt

Transepithelial Cl(-) secretion mediated by apical cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels plays a key role in cyst fluid accumulation in autosomal dominant polycystic kidney disease (ADPKD). The molecular identity of the basolateral transporter(s) responsible for Cl(-) entry in ADPKD cells is unknown, although pharmacological studies suggest that a bumetanide-sensitive...

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Share to Anion Exchange Protein 1, Erythrocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cystic Fibrosis Transmembrane Conductance Regulator

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Source

Identifiers

PMID: 12355171
DOI: 10.1007/s00424-002-0880-3

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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