Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tropism of human cytomegalovirus for endothelial cells is determined by a post-entry step dependent on efficient translocation to the nucleus.

The Journal of general virology - 1 Dec 2000

Sinzger C, Kahl M, Laib K, Klingel K, Rieger P, Plachter B, Jahn G

Abstract excerpt

Marked interstrain differences in the endothelial cell (EC) tropism of human cytomegalovirus (HCMV) isolates have been described. This study aimed to define the step during the replicative cycle of HCMV that determines this phenotype. The infection efficiency of various HCMV strains in EC versus fibroblasts was quantified by immunodetection of immediate early (IE), early and late viral antigens. Adsorption and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Adsorption

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Viral

Share to Cytomegalovirus

Share to Endothelium

Share to Genes, Immediate-Early

Share to Immediate-Early Proteins

Share to Umbilical Veins

Source

Identifiers

PMID: 11086133
DOI: 10.1099/0022-1317-81-12-3021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tropism of human cytomegalovirus for endothelial cells is determined by a post-entry step dependent on efficient translocation to the nucleus.PMID 11086133Read ↗

In vitro selection of human cytomegalovirus variants unable to transfer virus and virus products from infected cells to polymorphonuclear leukocytes and to grow in endothelial cells.Semantic proximity Read ↗

Improvement of a quantitative cell tropism assay for rapid and reliable characterization of human cytomegalovirus mutants.Semantic proximity Read ↗

Human Cytomegalovirus Tropism for Endothelial Cells: Not All Endothelial Cells Are Created EqualSemantic proximity Read ↗

Endothelial cells in human cytomegalovirus infection: One host cell out of many or a crucial target for virus spread?Semantic proximity Read ↗

Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implicationsSemantic proximity Read ↗

Modification of human cytomegalovirus tropism through propagation in vitro is associated with changes in the viral genome.Semantic proximity Read ↗

HCMV Spread and Cell Tropism are Determined by Distinct Virus PopulationsSemantic proximity Read ↗

Human Cytomegalovirus <i>UL135</i> and <i>UL136</i> Genes Are Required for Postentry Tropism in Endothelial CellsSemantic proximity Read ↗

Human Cytomegalovirus Persistently Infects Aortic Endothelial CellsSemantic proximity Read ↗

Quantification of replication of clinical cytomegalovirus isolates in cultured endothelial cells and fibroblasts by a focus expansion assaySemantic proximity Read ↗

Rescue of human cytomegalovirus strain AD169 tropism for both leukocytes and human endothelial cellsSemantic proximity Read ↗

An Endothelial Cell-Specific Requirement for the <i>UL133-UL138</i> Locus of Human Cytomegalovirus for Efficient Virus MaturationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.