Article
Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2000
Tai Y T, Teoh G, Lin B, Davies F E, Chauhan D, Treon S P, Raje N, Hideshima T, Shima Y, Podar K, Anderson K C
Abstract excerpt
Ku is a heterodimer of Ku70 and Ku86 that binds to double-stranded DNA breaks (DSBs), activates the catalytic subunit (DNA-PKcs) when DNA is bound, and is essential in DSB repair and V(D)J recombination. Given that abnormalities in Ig gene rearrangement and DNA damage repair are hallmarks of multiple myeloma (MM) cells, we have characterized Ku expression and function in human MM cells. Tumor cells...
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