Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs.

doi:10.1038/370065a0

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Article

Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs.

Nature - 7 Jul 1994

Colledge W H, Carlton M B, Udy G B, Evans M J

Abstract excerpt

The c-mos proto-oncogene encodes a 37-39K cytoplasmic serine/threonine kinase implicated in the meiotic maturation events during murine spermatogenesis and oogenesis. In Xenopus, ectopic expression of pp39mos can promote both the meiotic maturation of oocytes and also arrest the cleavage of blast...

Topics

Animals
Cells, Cultured
Chorionic Gonadotropin
Female
Fertility
Gametogenesis
Genes, mos
Male
Meiosis
Mice
Mice, Inbred C57BL
Mutation
Ovarian Cysts
Ovum
Parthenogenesis
Proto-Oncogene Proteins c-mos

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