Article
beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
Diabetes - 1 Nov 2000
Horikawa Y, Horikawa Y, Cox N J, Iwasaki N, Ogata M, Iwamoto Y, Schwitzgebel V, German M S, Bell G I
Abstract excerpt
The basic helix-loop-helix (bHLH) family of transcription factors plays an important role in the normal development and function of the endocrine pancreas. Heterozygous mutations in the gene encoding one member of this family, NeuroD1/BETA2, are associated with a monogenic form of diabetes that r...
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