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Article

No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France.

Diabetologia - 1 Apr 1999

Dupont S, Vionnet N, Chèvre J C, Gallina S, Dina C, Seino Y, Yamada Y, Froguel P

Abstract excerpt

AIMS/HYPOTHESIS: The identification of mutations in hepatocyte nuclear factors-1alpha, -4alpha, -1beta and insulin promoter factor-1 in maturity onset diabetes of the young (MODY) has highlighted the role that transcription factors may have in the development of diabetes. This result has focused...

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Source

Identifiers

PMID: 10230653
DOI: 10.1007/s001250051182

Genes

NEUROD1
PAX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10230653-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France.PMID 10230653Read ↗

Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.Semantic proximity Read ↗

beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.Semantic proximity Read ↗

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.Semantic proximity Read ↗

Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians.Semantic proximity Read ↗

No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.Semantic proximity Read ↗

[Molecular background and clinical characteristics of autosomal dominant type 2 diabetes mellitus].Semantic proximity Read ↗

MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1.Semantic proximity Read ↗

Identification of a new mutation in the hepatocyte nuclear factor-1alpha gene in a Polish family with early-onset type 2 diabetes mellitus.Semantic proximity Read ↗

A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes: studies of HNF4A variants in the Norwegian MODY registry.Semantic proximity Read ↗

Nuclear factors and type 2 diabetes.Semantic proximity Read ↗

A novel PAX4 mutation in a Japanese patient with maturity-onset diabetes of the young.Semantic proximity Read ↗

Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.Semantic proximity Read ↗

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