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Nonsense and Missense Mutations in the Human Hepatocyte Nuclear Factor-1β Gene (<i>TCF2</i>) and Their Relation to Type 2 Diabetes in Japanese

1 Aug 2002

Abstract excerpt

Mutations in transcription factors expressed in the pancreatic beta-cell are a major cause of maturity-onset diabetes of the young (MODY). They have also been found in patients diagnosed with type 1 and type 2 diabetes mellitus, which may highlight the difficulty in diagnosing these forms of diabetes or perhaps indicate a direct role in the development of multiple forms of diabetes. We have screened the...

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PMID: 12161522
DOI: 10.1210/jcem.87.8.8776

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