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Article

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

7 Apr 2010

Abstract excerpt

Hydroxyurea has proven clinical efficacy in patients with sickle cell disease. Potential mechanisms for the beneficial effects include fetal hemoglobin induction and the reduction of cell adhesive properties, inflammation and hypercoagulability. Using a murine model of sickle cell disease in which fetal hemoglobin induction does not occur, we evaluated whether hydroxyurea administration would still yield...

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Identifiers

PMID: 20378564
DOI: 10.3324/haematol.2010.023325

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