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Article

Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer.

Human mutation - 1 Jan 1996

Jeon H M, Lynch P M, Howard L, Ajani J, Levin B, Frazier M L

Abstract excerpt

We examined 18 unrelated individuals who have colorectal cancer or cancers associated with the HNPCC syndrome and have a family history of cancer for mutations in exon 13 of the hMSH2 gene. Two of the 18 individuals had the same previously unreported single-base deletion in codon 705 of hMSH2, resulting in a frame-shift mutation. Two other individuals had a T-to-C base change in the intron sequence at -6 position...

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Identifiers

PMID: 8723682
DOI: 10.1002/(SICI)1098-1004(1996)7:4<327::AID-HUMU6>3.0.CO;2-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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