Article
Multiple endocrine neoplasia type 2: A review.
Seminars in cancer biology - 1 Feb 2022
Mathiesen Jes Sloth, Effraimidis Grigoris, Rossing Maria, Rasmussen Åse Krogh, Hoejberg Lise, Bastholt Lars, Godballe Christian, Oturai Peter, Feldt-Rasmussen Ulla
Abstract excerpt
Multiple endocrine neoplasias are rare hereditary syndromes some of them with malignant potential. Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome due to germline variants in the REarranged during Transfection (RET) proto-oncogene. There are two distinct clinical entities: MEN 2A and MEN 2B. MEN 2A is associated with medullary thyroid carcinoma (MTC),...
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