Article
Familial adenomatous polyposis: The practical applications of clinical and molecular screening.
Familial cancer - 1 Jan 2006
Rozen Paul, Macrae Finlay
Abstract excerpt
Familial adenomatous polyposis (FAP) is an autosomal dominant condition mostly due to a mutation of the APC gene on the chromosome 5q. Carriers have an almost 100% chance of developing colorectal cancer after having multiple (typically 100s to 1000s) of adenomatous polyps. It is usually readily identified through this phenotype of multiple adenomas. Correlations between the location of the family-specific...
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