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Article

Quantitative analysis of estrogen receptor-beta mRNA and its variants in human breast cancers.

International journal of cancer - 1 Dec 2000

Iwao K, Miyoshi Y, Egawa C, Ikeda N, Noguchi S

Abstract excerpt

We have carried out a quantitative analysis of ER-alpha and ER-beta mRNA expression in normal (n = 11) and breast cancer (n = 112) tissues using a real-time (Taq-Man) PCR assay. Expression of ER-beta mRNA variants has also been studied by triple-primer PCR assay. ER-alpha mRNA levels in normal breast tissues were significantly (p < 0.01) lower than those in ER-positive breast cancers but not significantly...

Topics

Adult
Aged
Alternative Splicing
Breast Neoplasms
Estrogen Receptor alpha
Estrogen Receptor beta
Female
Genetic Markers
Genetic Variation
Humans
Middle Aged
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

RNA, Messenger

Receptors, Estrogen

Source

Identifiers

PMID: 11072241
DOI: 10.1002/1097-0215(20001201)88:5<733::aid-ijc8>3.0.co;2-m

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