Article
Quantitative profile of estrogen receptor variants/isoforms in Taiwanese women with breast cancer.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Jun 2006
Hsiao W-C, Cho W-C, Lin P-W, Lin S-L, Lee W-Y, Young K-C
Abstract excerpt
AIM: To quantify ER variants/isoforms for women with breast cancer in Taiwan, an area with remarkably low breast cancer rates, but with an early onset and poor prognosis. METHODS: Real-time PCR technology was exploited to quantify mRNAs of ERalpha, ERalphaE3Delta, ERalphaE5Delta, ERalphaE7Delta and ERbeta, in 49 breast cancer and paired adjacent normal tissues. Clinical parameters were assembled and tested for...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Breast
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Case-Control Studies
- Down-Regulation
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Female
- Genetic Variation