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An in vivo competitive repopulation assay for various sources of human hematopoietic stem cells

15 Nov 2000

Abstract excerpt

The marrow repopulating potential (MRP) of different sources of human hematopoietic stem cells (HSCs) was directly compared using an in vivo assay in which severe combined immunodeficient disease (SCID) mice were implanted with human fetal bones. HSCs from 2 human lymphocyte antigen (HLA)-mismatched donors were injected individually or simultaneously into the fetal bones of a 3rd distinct HLA type and donor and...

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PMID: 11071636
DOI: 10.1182/blood.v96.10.3414

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