Article
Sequence interruptions confer differential stability at microsatellite alleles in mismatch repair-deficient cells.
Human molecular genetics - 1 Nov 2000
Bacon A L, Farrington S M, Dunlop M G
Abstract excerpt
Determinants of instability at a given microsatellite repeat merits investigation in view of relevance to understanding evolution of mutations at such sequences in human populations. The microsatellite D2S123 was studied as a paradigm CA repeat marker. Furthermore, this marker is one of a recommended panel used in molecular screening for hereditary non-polyposis colorectal cancer (HNPCC). In this investigation we...
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