Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.

Genetics - 1 Nov 2000

Green C, Levashina E, McKimmie C, Dafforn T, Reichhart J M, Gubb D

Abstract excerpt

Mutants of the necrotic (nec) gene in Drosophila melanogaster die in the late pupal stage as pharate adults, or hatch as weak, but relatively normal-looking, flies. Adults develop black melanized spots on the body and leg joints, the abdomen swells with hemolymph, and flies die within 3 or 4 days of eclosion. The TOLL-mediated immune response to fungal infections is constitutively activated in nec mutants and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multigene Family

Share to Necrosis

Share to Protein Structure, Secondary

Share to Sequence Deletion

Share to Serpins

Source

Open in PubMed Open full text

Identifiers

PMID: 11063688
DOI: 10.1093/genetics/156.3.1117
PMCID: PMC1461326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.PMID 11063688Read ↗

Arabidopsis thaliana serpins AtSRP4 and AtSRP5 negatively regulate stress-induced cell death and effector-triggered immunity induced by bacterial effector AvrRpt2.Semantic proximity Read ↗

An immune-responsive Serpin regulates the melanization cascade in Drosophila.Semantic proximity Read ↗

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation.Semantic proximity Read ↗

A serpin that regulates immune melanization in the respiratory system of Drosophila.Semantic proximity Read ↗

Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.Semantic proximity Read ↗

Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis.Semantic proximity Read ↗

Widely Used Mutants of eiger, Encoding the Drosophila Tumor Necrosis Factor, Carry Additional Mutations in the NimrodC1 Phagocytosis Receptor.Semantic proximity Read ↗

The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll PathwaySemantic proximity Read ↗

Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33.Semantic proximity Read ↗

Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approachesSemantic proximity Read ↗

The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiaeSemantic proximity Read ↗

Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.