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Article

Packaging cell line characteristics and optimizing retroviral vector titer: the National Gene Vector Laboratory experience.

Human gene therapy - 10 Oct 2000

Reeves L, Smucker P, Cornetta K

Abstract excerpt

During the production of clinical-grade retroviral vector supernatant, we noted significant differences in the lactate production and glucose consumption of various producer cell lines submitted to the National Gene Vector Laboratory (NGVL). Since differences in growth characteristics could be important in determining the optimal culture conditions for maximizing titer, we studied the growth characteristics of...

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PMID: 11044911
DOI: 10.1089/104303400750001408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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