Article
The hepatitis B virus pregenome: prediction of RNA structure and implications for the emergence of deletions.
Intervirology - 1 Jan 2000
Kidd-Ljunggren K, Zuker M, Hofacker I L, Kidd A H
Abstract excerpt
The terminally redundant pregenomic RNA of human hepatitis B virus (HBV) comprises some 3,330 nucleotides and is a replicative intermediate in the production of the circular DNA genome. Deletions are known to arise in the HBV genome during the course of chronic infection and are sometimes associated with interferon therapy. These deletions are limited to small parts of the genome such as the 357-nucleotide pre-S1...
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