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Article

Transcription Factors Zic1 and Zic2 Bind and Transactivate the Apolipoprotein E Gene Promoter

1 Jan 2001

Abstract excerpt

We have used the yeast one-hybrid system to identify transcription factors that bind to specific sequences in proximal regions of the apolipoprotein E gene promoter. The sequence between -163 and -124, that has been previously defined as a functional promoter element, was used as a bait to screen a human brain cDNA library. Ten cDNA clones that encoded portions of the human Zic1 (five clones) and Zic2 (five...

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PMID: 11038359
DOI: 10.1074/jbc.m007008200

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