Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

doi:10.1128/AAC.44.11.3101-3106.2000

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Article

Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

Antimicrobial agents and chemotherapy - 1 Nov 2000

Adrian P V, Mendrick C, Loebenberg D, McNicholas P, Shaw K J, Klugman K P, Hare R S, Black T A

Abstract excerpt

Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16) were further analyzed. Whole chromosomal DNA or PCR products of the 23S ribosomal DNA (rDNA)...

Topics

Alleles
Aminoglycosides
Anti-Bacterial Agents
Bacterial Proteins
Base Sequence
DNA, Bacterial
Drug Resistance, Microbial
Humans
Microbial Sensitivity Tests
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

RNA, Bacterial

RNA, Ribosomal, 23S

Streptococcus pneumoniae

Transformation, Bacterial

Source

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Identifiers

PMID: 11036030
DOI: 10.1128/AAC.44.11.3101-3106.2000
PMCID: PMC101610

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