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Article

Effects of mutations in ribosomal protein L16 on susceptibility and accumulation of evernimicin.

Antimicrobial agents and chemotherapy - 1 Jan 2001

McNicholas P M, Mann P A, Najarian D J, Miesel L, Hare R S, Black T A

Abstract excerpt

Chemical mutagenesis of Staphylococcus aureus RN450 generated two strains that displayed a stable reduction (30- to 60-fold) in susceptibility to evernimicin. Cell-free translation reactions demonstrated that the resistance determinant was located in the ribosomal fraction. Compared to ribosomes isolated from a wild-type strain, ribosomes from the mutant strains displayed an 8- to 10-fold reduction in affinity...

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Identifiers

PMID: 11120948
DOI: 10.1128/AAC.45.1.79-83.2001
PMCID: PMC90243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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