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Article

Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: pathologic and molecular studies.

The Journal of pediatrics - 1 Oct 2000

Mircescu H, Parma J, Huot C, Deal C, Oligny L L, Vassart G, Van Vliet G

Abstract excerpt

We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11035845
DOI: 10.1067/mpd.2000.108437

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11035845-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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