Article
Residual thyroid tissue after thyroidectomy in a patient with TSH receptor-activating mutation presenting as a neck mass.
The Journal of clinical endocrinology and metabolism - 1 Feb 2013
Singer Kanakadurga, Menon Ram K, Lesperance Marci M, McHugh Jonathan B, Gebarski Stephen S, Avram Anca M
Abstract excerpt
BACKGROUND: Activating mutations of the TSH receptor (TSHR) are rare, with few reported cases of long-term follow-up. CASE: We present a follow-up report on a patient with neonatal thyrotoxicosis known to have a rare activating mutation of the TSHR, a heterozygous substitution in exon 10 (p.Ile568Thr). Initial treatment included total thyroidectomy at age 2 ½ years, resulting in iatrogenic hypothyroidism and...
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