Article
Single nucleotide polymorphism mapping using genome-wide unique sequences.
Genome research - 1 Jul 2002
Chen Leslie Y Y, Lu Szu-Hsien, Shih Edward S C, Hwang Ming-Jing
Abstract excerpt
As more and more genomic DNAs are sequenced to characterize human genetic variations, the demand for a very fast and accurate method to genomically position these DNA sequences is high. We have developed a new mapping method that does not require sequence alignment. In this method, we first identified DNA fragments of 15 bp in length that are unique in the human genome and then used them to position single...
Topics
- Chromosome Mapping
- Databases, Genetic
- Genetic Markers
- Genetic Variation
- Genome, Human
- Humans
- Polymorphism, Single Nucleotide