Article
The amino acid region 115-119 of ammodytoxins plays an important role in neurotoxicity.
Biochemical and biophysical research communications - 5 Oct 2000
Ivanovski G, Copic A, Krizaj I, Gubensek F, Pungercar J
Abstract excerpt
Quadruple (Y115K/I116K/R118M/N119L) and double (Y115K/I116K) mutants of ammodytoxin A, a presynaptically toxic phospholipase A(2) from Vipera ammodytes ammodytes venom, were prepared and characterized. The enzymatic activity of the quadruple mutant on phosphatidylcholine micelles was threefold hi...
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