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Article

Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from Viperidae venom.

Toxicon : official journal of the International Society on Toxinology - 15 Sept 2012

Faure Grazyna, Saul Frederick

Abstract excerpt

This review will focus on a description of the three-dimensional structures of two β-neurotoxins, the monomeric PLA(2) ammodytoxin from Vipera ammodytes ammodytes, and heterodimeric crotoxin from Crotalus durissus terrificus, and a detailed structural analysis of their multiple functional sites. We have recently determined at high resolution the crystal structures of two natural isoforms of ammodytoxin (AtxA and...

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PMID: 22683534
DOI: 10.1016/j.toxicon.2012.05.009

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