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Article

Recombinant Measles Viruses Efficiently Entering Cells through Targeted Receptors

1 Nov 2000

Abstract excerpt

We sought proof of principle that one of the safest human vaccines, measles virus Edmonston B (MV-Edm), can be genetically modified to allow entry via cell surface molecules other than its receptor CD46. Hybrid proteins consisting of the epidermal growth factor (EGF) or the insulin-like growth factor 1 (IGF1) linked to the extracellular (carboxyl) terminus of the MV-Edm attachment protein hemagglutinin (H) were...

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Identifiers

PMID: 11024120
DOI: 10.1128/jvi.74.21.9928-9936.2000

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