Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.

The Journal of biological chemistry - 5 Jan 2001

Kumar A, Novoselov V, Celeste A J, Wolfman N M, ten Dijke P, Kuehn M R

Abstract excerpt

Nodal, a member of the transforming growth factor beta (TGF-beta) superfamily, is implicated in many events critical to the early vertebrate embryo, including mesoderm formation, anterior patterning, and left-right axis specification. Here we define the intracellular signaling pathway induced by recombinant nodal protein treatment of P19 embryonal carcinoma cells. Nodal signaling activates pAR3-Lux, a luciferase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activins
Share to Embryonal Carcinoma Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Substances

Share to Inhibins

Share to Nodal Protein

Share to Smad2 Protein

Share to Smad3 Protein

Share to Xenopus Proteins

Source

Identifiers

PMID: 11024047
DOI: 10.1074/jbc.M004649200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.PMID 11024047Read ↗

Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloidsSemantic proximity Read ↗

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction.Semantic proximity Read ↗

cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)Semantic proximity Read ↗

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.Semantic proximity Read ↗

Patterning of the zebrafish embryo by nodal signals.Semantic proximity Read ↗

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.Semantic proximity Read ↗

Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.Semantic proximity Read ↗

Two distinct domains in pro-region of Nodal-related 3 are essential for BMP inhibition.Semantic proximity Read ↗

Characterization of a bone morphogenetic protein-responsive Smad-binding element.Semantic proximity Read ↗

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.Semantic proximity Read ↗

Control of embryonic Xenopus morphogenesis by a Ral-GDS/Xral branch of the Ras signalling pathway.Semantic proximity Read ↗

Nucleo-cytoplasmic shuttling of Axin, a negative regulator of the Wnt-beta-catenin Pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.