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Article

Genome-wide RNAi screen for host factors required for intracellular bacterial infection.

Science (New York, N.Y.) - 19 Aug 2005

Agaisse Hervé, Burrack Laura S, Philips Jennifer A, Rubin Eric J, Perrimon Norbert, Higgins Darren E

Abstract excerpt

Most studies of host-pathogen interactions have focused on pathogen-specific virulence determinants. Here, we report a genome-wide RNA interference screen to identify host factors required for intracellular bacterial pathogenesis. Using Drosophila cells and the cytosolic pathogen Listeria monocytogenes, we identified 305 double-stranded RNAs targeting a wide range of cellular functions that altered L....

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PMID: 16020693
DOI: 10.1126/science.1116008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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