Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rotaviral enterotoxin nonstructural protein 4 targets mitochondria for activation of apoptosis during infection.

The Journal of biological chemistry - 12 Oct 2012

Bhowmick Rahul, Halder Umesh Chandra, Chattopadhyay Shiladitya, Chanda Shampa, Nandi Satabdi, Bagchi Parikshit, Nayak Mukti Kant, Chakrabarti Oishee, Kobayashi Nobumichi, Chawla-Sarkar Mamta

Abstract excerpt

Viruses have evolved to encode multifunctional proteins to control the intricate cellular signaling pathways by using very few viral proteins. Rotavirus is known to express six nonstructural and six structural proteins. Among them, NSP4 is the enterotoxin, known to disrupt cellular Ca(2+) homeostasis by translocating to endoplasmic reticulum. In this study, we have observed translocation of NSP4 to mitochondria...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Cytochromes c

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enterotoxins

Share to Gene Expression Regulation, Viral

Share to Haplorhini

Share to Mitochondrial ADP, ATP Translocases

Share to Rotavirus Infections

Share to Toxins, Biological

Source

Open in PubMed Open full text

Identifiers

PMID: 22888003
DOI: 10.1074/jbc.M112.369595
PMCID: PMC3471681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rotaviral enterotoxin nonstructural protein 4 targets mitochondria for activation of apoptosis during infection.PMID 22888003Read ↗

Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection.Semantic proximity Read ↗

Rotavirus nonstructural glycoprotein NSP4 alters plasma membrane permeability in mammalian cells.Semantic proximity Read ↗

Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronavirusesSemantic proximity Read ↗

The Effects of Swine Coronaviruses on ER Stress, Autophagy, Apoptosis, and Alterations in Cell MorphologySemantic proximity Read ↗

Critical role of cytochrome c1 and its cleavage in porcine reproductive and respiratory syndrome virus nonstructural protein 4-induced cell apoptosis via interaction with nsp4Semantic proximity Read ↗

MAVS Protein Is Attenuated by Rotavirus Nonstructural Protein 1Semantic proximity Read ↗

Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell deathSemantic proximity Read ↗

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severitySemantic proximity Read ↗

Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Induces Apoptosis Dependent on Its 3C-Like Serine Protease ActivitySemantic proximity Read ↗

Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosisSemantic proximity Read ↗

Viroporin activity from rotavirus nonstructural protein 4 induces intercellular calcium waves that contribute to pathogenesisSemantic proximity Read ↗

MAVS-Mediated Apoptosis and Its Inhibition by Viral ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.