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Article

The yeast mitochondrial leucyl-tRNA synthetase is a splicing factor for the excision of several group I introns.

Molecular & general genetics : MGG - 1 Nov 1990

Labouesse M

Abstract excerpt

The Saccharomyces cerevisiae nuclear gene NAM2 codes for mitochondrial leucyl-tRNA synthetase (mLRS). Herbert et al. (1988, EMBO J 7:473-483) proposed that this protein is involved in mitochondrial RNA splicing. Here we present the construction and analyses of nine mutations obtained by creating two-codon insertions within the NAM2 gene. Three of these prevent respiration while maintaining the mitochondrial...

Topics

Cell Nucleus
Escherichia coli
Genes, Fungal
Genetic Vectors
Genotype
Introns
Leucine-tRNA Ligase
Mitochondria
Models, Biological
Mutagenesis, Insertional
Plasmids
RNA Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Fungal

RNA, Messenger

Restriction Mapping

Saccharomyces cerevisiae

Source

Identifiers

PMID: 2277640
DOI: 10.1007/BF00271554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2277640-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The yeast mitochondrial leucyl-tRNA synthetase is a splicing factor for the excision of several group I introns.PMID 2277640Read ↗

Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron.Semantic proximity Read ↗

Systematic screening of nuclear encoded proteins involved in the splicing metabolism of group II introns in yeast mitochondria.Semantic proximity Read ↗

An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing.Semantic proximity Read ↗

NAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes.Semantic proximity Read ↗

The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.Semantic proximity Read ↗

Critical base substitutions that affect the splicing and/or homing activities of the group I intron bi2 of yeast mitochondria.Semantic proximity Read ↗

Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.Semantic proximity Read ↗

nMAT4, a maturase factor required for nad1 pre-mRNA processing and maturation, is essential for holocomplex I biogenesis in Arabidopsis mitochondria.Semantic proximity Read ↗

nMAT1, a nuclear-encoded maturase involved in the trans-splicing of nad1 intron 1, is essential for mitochondrial complex I assembly and function.Semantic proximity Read ↗

A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria.Semantic proximity Read ↗

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AtnMat2, a nuclear-encoded maturase required for splicing of group-II introns in Arabidopsis mitochondria.Semantic proximity Read ↗

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