Article
The use of ancestral haplotypes in the molecular diagnosis of familial breast cancer.
Genetic testing - 1 Jan 2007
Frosk Patrick, Burgess Susan, Dyck Tamara, Jobse Rick, Spriggs Elizabeth L
Abstract excerpt
Mutations in BRCA1 and BRCA2 account for about 40% of families with an inherited susceptibility to breast and/or ovarian cancer. Mutational analysis of these two genes has become the standard of care for families with a strong suggestion of inherited susceptibility. Methodologies for screening vary, but one of the more popular techniques is dHPLC, due to its combination of high sensitivity and low cost. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.