Article
The molecular analysis of BRCA1 and BRCA2: Next-generation sequencing supersedes conventional approaches.
Clinica chimica acta; international journal of clinical chemistry - 15 Jun 2015
D'Argenio Valeria, Esposito Maria Valeria, Telese Antonella, Precone Vincenza, Starnone Flavio, Nunziato Marcella, Cantiello Piergiuseppe, Iorio Mariangela, Evangelista Eloisa, D'Aiuto Massimiliano, Calabrese Alessandra, Frisso Giulia, D'Aiuto Giuseppe, Salvatore Francesco
Abstract excerpt
BACKGROUND: Accurate and sensitive detection of BRCA1/2 germ-line mutations is crucial for the clinical management of women affected by breast cancer, for prevention and, notably, also for the identification of at-risk healthy relatives. The most widely used methods for BRCA1/2 molecular analysis are Sanger sequencing, and denaturing high performance liquid chromatography (dHPLC) followed by the Sanger method....
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