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Article

Differential expression of p53 and p21 in low grade cervical squamous intraepithelial lesions infected with low, intermediate, and high risk human papillomaviruses

15 Sept 2000

Abstract excerpt

BACKGROUND: Basal cell tetrasomy in low grade squamous intraepithelial lesions of the cervix is associated with infection by high and intermediate risk but not low risk human papillomaviruses (HPVs). It is known that the viral E6 and E7 proteins interact with p53 and p21, respectively, altering cell cycle control and leading to chromosomal instability. In this study, p53 and p21 expression was analyzed in disomic...

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PMID: 11002226
DOI: 10.1002/1097-0142(20000915)89:6<1300::aid-cncr15>3.0.co;2-u

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