Article
Genetic determinants of Graves disease.
Molecular genetics and metabolism - 1 Jan 2000
Chistyakov D A, Savost'anov K V, Turakulov R I, Nosikov V V
Abstract excerpt
Basedow-Graves disease is an autoimmune thyroid syndrome. Genetic factors contribute to the pathogenesis of Graves disease, and current findings confirm that a number of genes may be involved in the development of autoimmune thyrotoxicosis. At present three loci, namely human leukocyte antigen (HLA, 6p21.3), cytotoxic T-lymphocyte-associated esterase-4 (CTLA4, 2q33), and thyroid-stimulating hormone receptor...
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