DNA damage promotes mistyping in the allele specific oligonucleotide probing analysis of forensic samples.

doi:10.1002/1522-2683(20000801)21:14<2969::AID-ELPS2969>3.0.CO;2-7

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Article

DNA damage promotes mistyping in the allele specific oligonucleotide probing analysis of forensic samples.

Electrophoresis - 1 Aug 2000

Fattorini P, Cossutta F, Giulianini P, Edomi P, Previderè C

Abstract excerpt

Five polymerase chain reaction (PCR) products which could not be reliably typed by allele-specific oligonucleotide (ASO) probing at the human leukocyte antigen (HLA) DQA1 locus were analyzed by polyacrylamide gel electrophoresis and direct sequencing. The first method revealed the preferential amplification of only one of the two alleles in two cases. Direct sequencing of PCR products allowed unambiguous genetic...

Topics

Alleles
DNA Damage
DNA Primers
HLA Antigens
Humans
Polymerase Chain Reaction
Sensitivity and Specificity

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Identifiers

PMID: 11001311
DOI: 10.1002/1522-2683(20000801)21:14<2969::AID-ELPS2969>3.0.CO;2-7

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