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Article

Photo-induced inactivation of protein kinase calpha by dequalinium inhibits motility of murine melanoma cells.

Molecular pharmacology - 1 Oct 2000

Sullivan R M, Stone M, Marshall J F, Uberall F, Rotenberg S A

Abstract excerpt

Dequalinium (DECA) is a potent antitumor agent and inhibitor of protein kinase C (PKC). Previously it was shown that PKCalpha activity in vitro could be irreversibly inhibited when treated with DECA at low micromolar concentrations and irradiated with 366 nm of light. This approach was used to probe the role of intracellular PKC activity in the motility of metastatic murine melanoma B16 F10 cells and as a target...

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Source

Identifiers

PMID: 10999942
DOI: 10.1124/mol.58.4.729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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