Article
A role for the fibrinogen-binding regions of streptococcal M proteins in phagocytosis resistance.
Molecular microbiology - 1 Sept 2000
Ringdahl U, Svensson H G, Kotarsky H, Gustafsson M, Weineisen M, Sjöbring U
Abstract excerpt
All virulent group A streptococcal isolates bind fibrinogen, a property that is closely linked to expression of type-specific antiphagocytic surface molecules designated M proteins. Here we show that although the M proteins from two different strains, M1 and M5, both bind fibrinogen with high affinity, they interact with different regions in the ligand. Moreover, mapping experiments demonstrated that the...
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