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Article

Cloning and analysis of the gene encoding the human neonatal Fc receptor

1 Aug 2000

Abstract excerpt

The neonatal Fc receptor, FcRn, is expressed in human placental syncytiotrophoblast, capillary endothelium, intestinal epithelium, and other tissues. By analogy with its role in the mouse, human FcRn is expected to transport maternal IgG to the foetus, and protect circulating IgG from catabolism. The larger subunit of FcRn is homologous to the alpha chains of the major histocompatibility complex (MHC) class I...

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Identifiers

PMID: 10998088
DOI: 10.1046/j.1365-2370.2000.00225.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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