Article
No evidence for association between the KCNQ3 gene and susceptibility to idiopathic generalized epilepsy.
Epilepsy research - 1 Nov 2000
Haug K, Hallmann K, Horvath S, Sander T, Kubisch C, Rau B, Dullinger J, Beyenburg S, Elger C E, Propping P, Heils A
Abstract excerpt
Idiopathic generalized epilepsy (IGE) comprises a heterogeneous group of disorders, in which a high genetic predisposition and a complex mode of inheritance have been suggested. Recent identification of ion channel gene mutations in Mendelian epileptic disorders suggests genetically driven neuronal hyperexcitability as one important factor in epileptogenesis. Mutations in two neuronal voltage-gated potassium...
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