Article
The voltage-gated sodium channel beta2-subunit gene and idiopathic generalized epilepsy.
Neuroreport - 21 Aug 2000
Haug K, Sander T, Hallmann K, Rau B, Dullinger J S, Elger C E, Propping P, Heils A
Abstract excerpt
Recent identification of ion channel gene mutations in Mendelian epilepsies suggests that genetically driven neuronal hyperexcitability plays an important role in epileptogenesis. In this study, we tested the hypothesis that genetic variation in the human SCN2B gene confers liability to common subtypes of idiopathic generalized epilepsies (IGE). A systematic search for mutations was performed in 92 IGE patients....
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