Article
Evidence for microsatellite instability in bilateral breast carcinomas.
Cancer letters - 1 Jun 2000
Imyanitov E N, Togo A V, Suspitsin E N, Grigoriev M Y, Pozharisski K M, Turkevich E A, Hanson K P, Hayward N K, Chenevix-Trench G, Theillet C, Lavin M F
Abstract excerpt
The molecular pathogenesis of various categories of breast cancer (BC) has been well described, but surprisingly few reports have appeared on analysis of somatic mutations in bilateral BC. We have performed a polymerase chain reaction (PCR)-driven investigation of chromosomal regions showing common loss of heterozygosity (LOH) in 23 cases (46 tumors) from patients diagnosed with bilateral BC. LOH was observed in...
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