Article
Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells.
British journal of cancer - 1 Oct 2000
Sharrard R M, Maitland N J
Abstract excerpt
The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrounds, using gene constructs expressing either wt MMAC1 or various mutants deficient in the dual...
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