Cytotoxic necrotizing factor 1 (CNF1) induces an inflammatory response in the urinary tract in vitro but not in vivo.

doi:10.1016/j.toxicon.2008.03.019

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Article

Cytotoxic necrotizing factor 1 (CNF1) induces an inflammatory response in the urinary tract in vitro but not in vivo.

Toxicon : official journal of the International Society on Toxinology - 15 Jun 2008

Hertting Olof, Chromek Milan, Slamová Zuzana, Kádas Lavinia, Söderkvist Maja, Vainumäe Inga, Tallvik Tiina, Jacobson Stefan H, Brauner Annelie

Abstract excerpt

Cytotoxic necrotizing factor 1 (CNF1) is a well-defined virulence factor of uropathogenic Escherichia coli. We studied the role of CNF1 in uroepithelial cells as well as in children and adults with sporadic and recurrent UTI. Our study suggests that CNF1 may promote bacterial attachment and invasion and can induce an inflammatory response in the urinary tract in vitro but that its role in vivo is possibly minor...

Topics

Bacterial Toxins
Cells, Cultured
Epithelial Cells
Escherichia coli
Escherichia coli Proteins
Humans
Mutation
Tissue Inhibitor of Metalloproteinase-1
Urinary Tract
Urinary Tract Infections
Virulence Factors

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Identifiers

PMID: 18471840
DOI: 10.1016/j.toxicon.2008.03.019

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