Escherichia coli Uropathogenesis <i>In Vitro</i> : Invasion, Cellular Escape, and Secondary Infection Analyzed in a Human Bladder Cell Infection Model

Abstract excerpt

Uropathogenic Escherichia coli (UPEC) strains are capable of invading bladder epithelial cells (BECs) on the bladder luminal surface. Based primarily on studies in mouse models, invasion is proposed to trigger an intracellular uropathogenic cascade involving intracellular bacterial proliferation followed by escape of elongated, filamentous bacteria from colonized BECs. UPEC filaments on the mouse bladder...

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