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Uropathogenic E. coli induces DNA damage in the bladder

25 Feb 2021

Abstract excerpt

Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the cleavage product released during the synthesis of colibactin, a bacterial genotoxin, in 55 of the samples examined. Uropathogenic Escherichia coli strains isolated from these...

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PMID: 33630958
DOI: 10.1371/journal.ppat.1009310

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