Article
Novel hotspot detector software reveals a non-CpG hotspot of germline mutation in the factor IX gene (F9) in Latin Americans.
Human mutation - 1 Sept 2000
Drost J B, Scaringe W A, Jaloma-Cruz A R, Li X, Ossa D F, Kasper C K, Sommer S S
Abstract excerpt
Two-base substitutions at each of two nucleotides in the factor IX gene (F9), but not part of CpG dinucleotides, were recently reported in a small population sample collected in Mexico, a significant observation of recurrent sites ("hotspots") of mutation (P=0.00005). When these new data were combined with previously collected mutation data into two progressively larger and inclusive Latin American samples,...
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