Article
Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.
Gene - 22 Aug 2000
Nasir J, Lafuente M J, Duan K, Colomer V, Engelender S, Ingersoll R, Margolis R L, Ross C A, Hayden M R
Abstract excerpt
The huntingtin-associated protein (HAP-1) interacts with the Huntington disease gene product, huntingtin. It is predominantly expressed in the brain and shows an increased affinity for mutant huntingtin. We have sequenced an 18,656bp genomic region encompassing the entire human HAP-1 gene and determined its genomic organisation, with 11 exons spanning 12.1kb. We have also found an intragenic polymorphism within...
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