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Article

Inhibition of chromosome replication in Mycobacterium smegmatis: effect of the rpmH-dnaA promoter region.

Microbiology (Reading, England) - 1 Sept 2000

Salazar Leiria

Abstract excerpt

In a previous study a functional mycobacterial origin of replication, oriC, was isolated on a plasmid. However, it was found that origin function was inhibited by the presence of the adjacent dnaA gene or its regulatory region, so that plasmids containing both of these regions next to the origin did not yield transformants. This inhibition could be due either to overexpression of dnaA on a plasmid being toxic,...

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PMID: 10974107
DOI: 10.1099/00221287-146-9-2199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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