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Article

BUB1 infrequently mutated in human breast carcinomas.

Human mutation - 1 Nov 2003

Langerød Anita, Strømberg Maria, Chin Koei, Kristensen Vessela N, Børresen-Dale Anne-Lise

Abstract excerpt

The BUB1 gene is a key player in the mitotic spindle checkpoint machinery that monitors proper segregation of sister chromatides during mitosis. It has been suggested that mutations in BUB1 may disrupt the spindle checkpoint and thereby cause chromosomal instability, which is a hallmark of solid tumors including those from the breast. From a series of breast carcinomas we selected 20 cases with genomic...

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Identifiers

PMID: 14517964
DOI: 10.1002/humu.9194

Genes

BUB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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BUB1 infrequently mutated in human breast carcinomas.PMID 14517964Read ↗

Four single-nucleotide polymorphisms in the human BUB1 gene.Semantic proximity Read ↗

Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.Semantic proximity Read ↗

Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability.Semantic proximity Read ↗

No mutations of the Bub1 gene in human gastric and oral cancer cell lines.Semantic proximity Read ↗

Prevalence of germline mutations in the spindle assembly checkpoint gene BUB1B in individuals with early-onset colorectal cancer.Semantic proximity Read ↗

Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.Semantic proximity Read ↗

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.Semantic proximity Read ↗

No mutations of the Bub1 gene in human gastric carcinomas.Semantic proximity Read ↗

Germline Mutations in the Spindle Assembly Checkpoint Genes BUB1 and BUB3 Are Risk Factors for Colorectal CancerSemantic proximity Read ↗

A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T.Semantic proximity Read ↗

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Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer.Semantic proximity Read ↗

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